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Hepatic Veno-occlusive Disease or Sinusoidal Obstruction Syndrome is a clinical syndrome characterized by painful hepatomegaly, jaundice, ascites, edema and weight gain, which usually occurs as a complication of bone marrow transplantation. Clinical Case: We describe a new case of male school age 9 with Ewing Sarcoma who had Hepatic Veno-occlusive Disease secondary to chemotherapy with cyclophosphamide and vincristine. Evolution: We set the differential diagnosis from liver damage due to infection and autoimmune diseases through serological tests and biopsy. Conclusion: This is the first report that describes the association between Ewing Sarcoma and Hepatic Veno-occlusive Disease.

Caso clínico: Enfermedad Veno-Oclusiva Hepática secundaria a Quimioterapia en un paciente con Sarcoma de Ewing.