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This research work designates of interaction and complexation studies of Cefixime with essential metal. Cefixime involved the third generation drug of penicillin. In vitro analysis, Cefixime must be interacted with metal like Mg 2+ and Mn 2+ . At pH 7.4, this study was done in different ratios of cefixime with metal and antacid both at room temperature 25°C. By this study, it is investigated that drug Cefixime is complexed with metal as well as antacid which is confirmed by jobs plot. This experiment was carried out by using ultra violet spectrophotometer. The microbial sensitivity test is important to know whether there is any change in the effectivity of Cefixime after the interaction with metals. There was a remarkable change in the effectivity of Cefixime and its complexes. This research work confirms that there was interaction between Cefixime with Metals like Mg 2+ and Mn 2+ which was confirmed by Jobs plot method by spectrophotometric assay.

Complexation and Interaction Study of Antibiotic Cifixime with Essential Metals by Spectrophotometric Method