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Dysfunctions of Muscles of Mastication (MM) are commonly associated with facial pain, and it is a common medical condition in women's reproductive health. Hypothetically, sex hormones could be considered an underlying cause for this dysfunction, but few studies were done to explore sex hormones receptors in MM. The aim of the present study is to explore the effect of both age and sex on the expression of estrogen and androgen receptors in muscles of mastication. Eighty rats were randomly assigned into four groups. Group-12F, group-12M, group-24F and group-24M. After rats were sacrificed, MM were removed for histological and immunohistochemical examinations. Regardless age and sex, there was a weak expression of estrogen receptors (α,β) in all muscles. In group-24M, expression of androgen receptors in MM was significantly higher than that of other groups. In conclusion, the present study sheds the light on the age-related increased expression of androgen receptors in male albino wistar rats which could protect against temporomandibular muscles dysfunctions. Further studies are needed to evaluate this hypothesis for further clinical applications.

Expression of Androgen Receptors in Abating Age-Related Temporomandibular Muscles Dysfunctions in Female Albino Wistar Rats