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Biscoumarins’ properties are similar to those of coumarins and exhibit various biological activities. Bis-coumarins were usually prepared by the condensation of carbonyl compounds with 4-hydroxycoumarin in organic solvents which employs large amounts of hazardous and toxic solvents associated with catalysts. However, these protocols were not environmentally benign. Thus, the introduction of efficient new methods based on green methodology is still in great demand. In the course of our investigation to develop new green synthetic method we wish to report here in a simple, efficient and eco-friendly procedure for the synthesis of bis-coumarin derivatives by grinding the aromatic aldehyde and 4-hydroxy coumarin in the presence of grape juice as a natural catalyst. This is a convenient and facile one pot synthesis of bis-coumarin with a greener approach. Thus facilitating efficient synthesis of bioactive compounds in environmentally benign way with shorter reaction time, mild reaction conditions, easy workup, and more over less expensive with excellent yield of the product.

Grape juice catalyzed synthesis of Bis-coumarin derivatives by Grindstone Technique: A Green chemistry Approach.