Analysis of Tolnaftate - Review

Tolnaftate has been widely used as a kind of topical antifungal in the treatment of cutaneous disease such as Jock itch, athlete's foot and other skin infections due to, Epidermophyton, Microsporum, Trichophyton species, and Malassezia furfur. The aim of this review to focus on a comprehensive update of chromatography determination of Tolnaftate in bulk and in pharmaceutical preparations, tolnaftate preparations are available in powder, cream, ointment, gel, emulgel, Solution and spray. In which has been described using RP-HPLC, LC, HPTLC, UV methods, Indirect Spectrophotometric method, Isocratic Supercritical Fluid Chromatography, Indirect spectroflurometric method. Pharmacopeial methods and Titrimetric methods also studied in this review. This review provides detailed information on separation conditions for Tolnaftate alone, combinations with other drugs and in the presence of its degradation products.