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In this study, oil-in-water (O/W) system of microemulsion prepared to increase the solubility of poorly water soluble drug Aceclofenac which is a very efficient Non steroidal anti-inflammatory drug against serious diseases such as rheumatoid arthritis, as the poor solubility of Aceclofenac in water limits oral bioavailability. The solubility enhancers like different surfactants of Tween 80, Chremophor EL and Labrasol were used to solubilise the drug with medium chain triglycerides. The pseudoternary phase diagrams showed the suitability of selection of oils, surfactant and cosurfactant. Then Aceclofenac was mixed with the blend of Oil, surfactant, Cosurfactant to form homogeneous microemulsion followed by water titration. The microemulsion optimised by determination of mean droplet sizes, Zeta potential, viscosity, Invitro diffusion and In vivo studies. The droplet size of optimised formulation F2 was 87nm were successfully developed. They were able to improve the drug solubility up to 1000-fold. The zeta potential of -45mv showing the stability of microemulsion. The in-vitro drug diffusion of microemulsion through semi permeable membrane was compared with marketed formulation. The anti-inflammatory action of the formulation and the in-vivo absorption study investigation conducted in rat paw oedema experiment were significantly representing the efficacy of formulation.

Development and Evaluation of Novel Microemulsion Formulation for Oral Delivery of Aceclofenac.