English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A simple and robust analytical reversed-phase high-performance liquid chromatography method was developed and validated for Ziprasidone (ZPS) with Albendazole as internal standard drug. The method was developed in human plasma and dosage formulation with high-quality chromatographic separation between the drug peaks by using a stainless steel Reverse Phased analytical column C18 (25 cm, 4.6 mm id, 5 mm particle size). The system was operated at 25 o C using a mobile phase consisting of Phosphate buffer: acetonitrile [60:40, v/v] with pH adjusted 2.5 with ortho phosphoric acid in isocratic flow rate of 1 mL min -1 with ultraviolet detection ,UV 730 D monitored at 230 nm. The parametric statistics, i.e., correlation coefficient of 0.999, was assessed for all the drugs having linearity over the tested concentration range (15-500 ng mL -1 ) in plasma using calibration curve. The accuracy of samples for six replicate measurements at lower limit of quantitation level was within limit. The method was applicable for the quality control of the mentioned drugs in raw material, bulk drug and pharmaceutical formulations as well as in pharmacokinetic studies.

A Validated Bioanalytical Method for Quantification of Ziprasidone in Human Plasma by RP-HPLC: Application to a Pharmacokinetic Study.