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In this study tumors were developed with carcinogenic agent 7-12 Dimethylbenz[a] anthracene (DMBA) in female albino wistar rats at a dose of 7.5 mg/kg sc. once in a week for 4 weeks and waited for 90 days considering from first day of initiation until development of tumors. Once tumors were developed at 90 days then tumor size was measured weekly with digital vernier caliper for four weeks during the treatment of plant extracts. Plant extracts of Curcuma zedoaria and Gloriosa superba comparatively evaluated for their potential to reduce tumor size against Paclitaxel. Administration of aqueous extracts of Curcuma zedoaria and Gloriosa superba at dose of 5mg/kg body weight orally for 30 days was associated with significant decrease in tumor volume as compare to that of Paclitaxel which was given at dose of 1mg/kg body weight i.p. Apart from this Curcuma zedoaria and Gloriosa superba aqueous plants extracts treated groups has shown significant down regulation of biological markers like SGPT, ALP, LDH, LPO, Urea, and up regulation of GSH, Total protein. Therefore Curcuma zedoaria and Gloriosa superba when administered orally can act as effective curative agent towards DMBA induced mammary tumors.

journal of current pharma research

Comparative Anticancer Evaluation of Curcuma zedoaria and Gloriosa superba against 7, 12-Dimethylbenz [a] anthracene (DMBA) Induced Mammary Tumors in Rats