Formulation and Evaluation of Mouth Dissolving Tablets of Buclizine HCl by Direct Compression Technique.

Aim of novel drug delivery system is to enhance safety and efficacy of drug molecule to achieve better patient compliance. One of the above advances is the formulation of mouth dissolving tablets (MDTs) which dissolve instantaneously. Within a few seconds the releasing of drug without the need of water. Main objective of this paper was to prepare and develop MDTs of Buclizine (BZ HCl) with sufficient mechanical integrity, content uniformity, and acceptable palatability to assist patients of any age for easy administration. Buclizine HCl is an anti-allergic drug used for management of allergic reactions. The MDTs of Buclizine HCl were prepared by direct compression method. The effect of varying concentrations of different superdisintegrants such as crospovidone, croscarmellose sodium, and sodium starch glycolate on disintegration time and dissolution rate was studied. The prepared tablets were evaluated for hardness, friability, disintegration time and in-vitro drug release. Results obtained conclusively demonstrated successful rapid disintegration of the formulated tablets and acceptable palatability.