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Aseries of 2benzyl – 3 {4[N'(3-substituted-5-oxo-1-substituted-1, 5dihydropyrazole-4-ylidene) hydrazino] phenyl}-3H-quinazoline-4-one, derivative were synthesized. The synthesized compounds were characterized by UV, IR, NMR, Mass spectral data. The synthesized compounds were screened for their antibacterial and antifungal activity against pathogenic bacteria and fungus. Compounds Q7, 3[4-(3, 5-dimethyl-1H-pyrazol-4-ylazo) phenyl]-2-benzyl-3H-quinazolin-4-one and Q3,2-benzyl-3-{4-[N'-(3-methyl-5-oxo-1-isonictinoylpyrazole-4-ylidene) hydrazino] phenyl} 3Hquinazoline-4 one exhibited good antibacterial and antifungal activity against the tested microorganisms.

Synthesis and Antimicrobial Screening of 3H-Quinazolin-4-Ones Containing 3-Methyl Pyrazolinone Moiety.