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The objective of this research was to prepare a gastroretentive drug delivery system of Stavudine. Gastric residence time can be increased by various approaches like high density dosage forms, swelling systems, expandable systems, mucoadhesive systems, and floating drug delivery systems etc. Effervescent floating drug delivery system of this class contains a highly swellable polymer and an effervescent agent. Guar gum, xanthan gum, and hydroxypropyl methylcellulose were evaluated for gel-forming properties. Sodium bicarbonate was incorporated as a gas-generating agent. The proportion of sodium bicarbonate was varied to get the least possible lag time, also the polymer part varied to get the desired release. Tablets were prepared by the dry granulation (slugging). Tablets were evaluated for their physical characteristics, in vitro buoyancy & drug release studies using United State Pharmacopoeia (USP) 24 paddle type dissolution type apparatus using 0.1N HCl as a dissolution medium for 12 hours. The tablets exhibited controlled and prolonged drug release profiles while floating over the dissolution medium. Non-Fickian diffusion was confirmed as the drug release mechanism from these tablets. The best formulation (F7) was selected based on floating characteristics.

Preparation and In Vitro Evaluation of Gastroretentive Tablets of Anti Retroviral Drug Using Different Polymers