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A wide controversy exists regarding the effect of NSAIDs on the oxidative status. Each member of these NSAIDs has been shown to act both as antioxidant or pro-oxidant in different test systems, using different concentrations and various oxidative stress-inducing agents. This review tackles this problem and tries to look for factors that might be responsible for this variation in results.

NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS), FREE RADICALS AND REACTIVE OXYGEN SPECIES (ROS): A REVIEW OF LITERATURE