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Colon cancer was a cancer type that could be death. One of the reason was the growth Leukotriene A4 hydrolase that were out of control. Leukotriene A4 hydrolase might be used as a therapeutic target in suppressing the growth of cancer cells. Bullatalicin asetogenin derivative was a compound that has the potential to inhibit Leukotriene A4 hydrolase. This study aims to determine the potential Bullatalicin as inhibitors in silico based on the Gibbs free energy (ΔG), inhibition constant, hydrogen bonding interactions and Root Mean Deviation Square (RMSD). The computationally study using molecular docking method. The results of docking interaction visualization, shows the bonding interactions between Bullatalicin and amino acid residues of the catalytic domain. In addition the value of Gibbs free energy, constant inhibition of Bullatalicin and RMSD not significantly different than the standard ligand. Therefore, Bullatalicin could be predicted as potential Leukotriene A4 hydrolase inhibitor.

POTENSI SENYAWA BULLATALISIN SEBAGAI INHIBITOR PROTEIN LEUKOTRIEN A4 HIDROLASE PADA KANKER KOLON SECARA IN SILICO