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Massoi (Cryptocarpa massoy) is one of of plants that has been used by the local people of Papua as traditional medicine. Part of the plant used is the bark that had extracted to produce oil. The utilization of Massoi bark by local communities all these times still less optimal, because studies related to the content of chemical compounds and efficacy of the use of bark Massoi pharmacologically are still limited. This study was conducted to identify bioactive compounds in ethyl acetate extract of the bark of Massoi and to its test activities as antibacterial, antioxidant and to determine its toxicity level. The bark of Massoi extracted by maceration method using methanol and partitioned with mixture of water : ethyl acetate (1:1). Ethyl acetate extract of bark of Massoi was tested for its phytochemical, and its antibacterial, antioxidants and toxicity. Furthermore, to identify the presence of specific compounds, separation, purification and identification by chromatography were done. Phytochemical test o ethyl acetate extract of bark Massoi group showed several compounds, i.e essential oils, flavonoids, tannins, steroids, triterpenoids and coumarin. The test results showed that the ethyl acetate extract of the bark Massoi have positive activity as cytotoxic compounds with LC50 of 12.12 ppm (extremely toxic) and showed its potency as a powerful antioxidant with IC50 of 44.02 ppm. Based on the results of compounds separation performed by column chromatography 7 factions were obtained grouped by their TLC chromatogram profile from column chromatography analysis results including stain shape, color, and retention time. HPLC analysis results found fractions with the largest area contained in fraction 4 at 95,042,975 at retention time of 10.050 minutes. The fraction 4 were analyzed by GC-MS to identify the components of compounds and obtained 13 compounds that have the greatest percent similarity between 95-99% of the GC-MS data Library program.

IDENTIFIKASI SENYAWA DAN UJI AKTIVITAS EKSTRAK ETIL ASETAT KULIT KAYU MASSOI