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Puspa (Schiima wallichii) are known to have anticancer activity through a mechanism induces apoptosis in breast cancer cells MCF-7, while the broccoli sprouts (Brassica olerasea) has been reported inhibit the proliferation of cancer cells of bladder and prostate in vitro. In this study the cytotoxicity assay of combination puspa extract (EP) and broccoli sprout extract (EKB) against breast cancer cell line MCF-7 were evaluated. IC50value of EP were 60.76 ug / ml, whereas EKB didn’t give a percentage inhibition greater than 50% in the tested concentration range. Cytotoxicity assay of combination EP-EKB with IC50 ratio of 1:2 showed higher cytotoxicity than EP or EKB alone in same concentration and given CI (combination index) value <0.9, indicates that the combination of EP-EKB had synergism effect.

SITOTOKSISITAS KOMBINASI EKSTRAK PUSPA (Schiima wallichii) DANKECAMBAH BROKOLI iv (Brassica olerasea) TERHADAP SEL KANKER PAYUDARA MCF-7