Open AccessIs Citrate A Critical Signal in Immunity and Inflammation?
Author(s) -
Alessia Zotta,
Zbigniew Zasłona,
Luke O'neill
Publication year - 2020
Publication title -
journal of cellular signaling
Language(s) - English
Resource type - Journals
ISSN - 2692-0638
DOI - 10.33696/signaling.1.017
Subject(s) - inflammation , immune system , microbiology and biotechnology , signal transduction , function (biology) , immunity , metabolic pathway , carbohydrate metabolism , citric acid cycle , chemistry , biology , biochemistry , metabolism , immunology
Krebs cycle, elucidated by Sir Hans Krebs, is a bioenergetic pathway occurring in the mitochondrial matrix of all eukaryotic organisms. It is an essential process for energy generation from diet carbon-based nutrients. Krebs was studying how bird muscle tissue takes up oxygen very quickly in the presence of carbohydrates and hypothesized that carbohydrate metabolism should occur through a cyclic series of reactions [5].
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