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Mantle cell lymphoma (MCL) is a rare subtype of nonHodgkin Lymphoma (NHL) characterized by cyclin D1 translocations [1-3]. Outcomes are heterogenous, but the disease is generally incurable. High-risk patients been shown to have a median overall survival (OS) of only 37 months and 20% five-year OS [4-6]. In some patients, the disease is more indolent; such cases are associated with leukemic phase of the disease, SOX11-negativity, and mutated IGHV [7,8]. Additionally, even across SOX11 positive cases outcomes vary, with worse overall survival in MCL with cytoplasmic staining as compared to nuclear staining [9]. For patients with indolent clinical behavior, observation is frequently employed, and large case series suggest the possibility of prolonged periods before treatment becomes necessary, as long as 128 months, and favorable outcomes even once treatment has been initiated [7,10].

Mantle Cell Lymphoma and Hematopoietic Cell Transplantation in the Era of Cellular Therapy