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Over the past 15 years, long non-coding RNAs (lncRNA) have emerged as an important class of regulatory molecules. The currently accepted definition is that lncRNA refers to RNA molecules with little or no protein-coding potential, and which are greater than 200 nucleotides in length, a size cut-off chosen largely to distinguish them from the more-extensively characterised group of small non-coding regulatory RNAs, which includes micro (mi)RNAs, small inhibitory (si)RNAs and PIWI-interacting (pi)RNAs [1]. A recent compilation of annotations from diverse sources identified nearly 57,000 genes encoding lncRNAs in the human genome [2].

Long Non-coding RNAs in the Pathophysiology of Multiple Myeloma: New Insights on the Role of CRNDE