English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Orientation of biological apatite (BAp) in hard tissues is very sensitive to the stress distribution in vivo.1,2 Analysis of the BAp orientation is therefore a useful method to examine mechanical properties of hard tissues. At present, however, the clinical diagnosis for pathological hard tissues is dominantly performed on the basis of BAp density, so-called bone mineral density (BMD).3 Osteoarthritis (OA) is one of a group of common bone diseases which are related degenerative disorders within an articular joint. The cartilage degeneration is closely related to the loss of bone structure under repeated loading. In this study, preferential alignment of BAp was analyzed on the subchondral bone in human knees with OA to clarify the effect of OA on the bone microstructure. A specimen of a knee with OA in a femur used in an operation replacing the knee with an artificial joint, was provided by Osaka City University Hospital and was judged to be grade III (Kellgren and Lawrence, 1957). The patient (a female aged 80 years old) gave informed consent for this study. The specimen was immersed in a 10% formalin neutral-buffered solution to suppress denaturation of the organic matrix. Before and after removal of cartilage on subchondral bone, X-ray diffraction measurement was performed using the microbeam X-ray diffractometer system (M18XHF22-SRA). Preferential alignment of the c-axis of the BAp crystallites was analyzed in the normal direction on the specimen surface. The detailed conditions for the X-ray diffraction analysis were described in our previous paper.2 Preferential orientation of BAp was determined by the relative intensity ratio of the (002) diffraction peak to the (310) peak. The analyzed positions were selected on the condyle of the femur from the imus point along the path of the center of

ANALYSIS OF PREFERENTIAL ALIGNMENT OF BIOLOGICAL APATITE CRYSTALLITES IN SUBCHONDRAL BONE OF THE OSTEOARTHRITIC KNEE