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Gestational diabetes mellitus (GDM) is closely associated with early perinatal complications and long-term health problems, such as cardiovascular disease, in offspring. AMP-activated protein kinase (AMPK) is cardioprotective, particularly in the treatment of ischemia/reperfusion (I/R). However, whether GDM programs offspring susceptibility to cardiac I/R and the involvement of AMPK remain unclear.

Blunted Cardiac AMPK Response is Associated with Susceptibility to Ischemia/ Reperfusion in Male Offspring of Gestational Diabetic Rats