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In a previous study, we reported that cardiomyocytes were equipped with non-neuronal cardiac cholinergic system (NNCCS) to synthesize acetylcholine (ACh), which is indispensable for maintaining the basic physiological cardiac functions. The aim of this study was to identify and characterize a pharmacological inducer of NNCCS.

cellular physiology and biochemistry

A Novel Nitric Oxide Donor, S-Nitroso-NPivaloyl- D-Penicillamine, Activates a Non- Neuronal Cardiac Cholinergic System to Synthesize Acetylcholine and Augments Cardiac Function