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microRNA-486-5p (miR-486-5p) and forkhead box protein O1 (FOXO1) play an important role in the development of intervertebral disc degeneration (IDD). However, their molecular mechanisms in IDD remain unknown.

cellular physiology and biochemistry

miR-486-5p Inhibits Inflammatory Response, Matrix Degradation, and Apoptosis of Nucleus Pulposus Cells Through Directly Targeting FOXO1 in Intervertebral Disc Degeneration