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Female Sprague-Dawley rats were fed a normal diet for 7 Days, then switched to an experimental diet for 48 hours. The experimental diets contained 0,100,200, 400 or 800ppm benzo[a]pyrene (B[a]P), with or without 10% Kanpyo powder. After 48 hours, the livers and small intestinal mucosa were analyzed for various drug-metabolizing enzyme activities. Intestinal arylhydrocarbon hydroxylase was significantly induced by 800 ppm B[a]P, but this enzyme induction was significantly inhibited by Kanpyo powder. These data might suggest that Kanpyo reduces exposure of the intestine to dietary carcinogenic polycyclic aromatic hydrocarbons such as B[a]P. (Received March 29, 1994)

Effects of Kanpyo Powder on Drug-Metabolizing Enzymes Induced by Benzo [a] pyrene in Rats