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Diphenyl, o-phenylphenol, piperonyl butoxide and thiabendazole were given to mice to confirm the potential ability of these compounds to modify the toxicity of other compounds. The acute oral toxicity (LD50) values of equitoxic combinations of these food additives with pesticides as model toxicants were determined with male mice. The expected LD50 of a mixture was calculated from Finney's equation, and compared with the observed LD50. The pesticides studied included BPMC, carbaryl, DDVP, diazinon, EPN, fenitrothion, malathion, nicotine, parathion, parathion-methyl and pyrethrins. All the above food additives increased the toxicity of BPMC, carbaryl, diazinon, EPN and parathion on the one hand, but decreased that of DDVP, fenitrothion, malathion and parathion-methyl on the other. (Received September 20, 1982)

Effects of Post-harvest Fungicides and Piperonyl Butoxide on the Acute Toxicity of Pesticides in Mice