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Chikens were given feed containing antibacterial agents at the maximum legal levels for 6 weeks and then control feed for up to 14 days. Chickens were sacrificed on days 0, 1, 2, 3, 5, 7, 10 and 14 after withdrawal of the drug and the drug concentrations in various tissues were determined. In addition, 3 hens for each drug were given drug-containing feed for 14 days and then control feed for a further 14 days, and all eggs laid during this period were analyzed.These antibacterials were readily eliminated within 3-5 days, except for nicarbazine, which remained detectable in tissues for 10 days and in eggs for 28 days. The biological half-lives of antibacterials were calculated to be 0.4-4.3 days from these data.

Residues of Synthetic Antibacterial Feed Additives in Tissues and Eggs of Chickens