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Objective: this study observes the changes of cognitive function, β-amyloid peptide (Aβ) and Brain-derived growth factor (BDNF) in circadian rhythm disturbances (CRDs). Method: Animal models of CRDs induced by light-dark cycles in different periods. Cognitive function in mice was detected by water maze test. BDNF and Aβ levels were determined ELISA Kit. Result: In CRDs, there were cognitive function declines, BDNF decreased and Aβ increased. Conclusion: CRDs can lead to cognitive function declines; it was related to BDNF decreased and Aβ increased.

Beta Amyloid, Brain-Derived Growth Factor and Cognitive Function in Circadian Rhythm Disturbances