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Solid pseudopapillary neoplasm pancreas SPN is a rare primary neoplasm of the pancreas that typically affects young women, SPN show nonspecific clinical presentation with vague radiologic features and are often histologically benign. We here report a 21-year-old Libyan girl presented with gradually progressing, episodic, abdominal pain accompanied by anorexia and significant weight loss (11 kg in 2 months), without any significant laboratory findings. On CT scan a heterogenous mass was found at the distal pancreas. The patient underwent distal pancreatectomy with spleen preserving operation with the presumptive diagnosis of Solid pseudopapillary neoplasm of the pancreas (SPN). The tumor was well-circumscribed, encapsulated, 17x12 cm in dimensions, 2.5 kg weight, the patient was not given any adjuvant therapy and shows no sign of disease after eight months follow-up Surgical decision should be built depend on information gained collectively from preoperative CT examination, intraoperative findings of tumor location, capsule integrity, and invaded surrounding tissues, immunohistochemical staining which lead to relatively clear diagnosis of solid pseudopapillary neoplasm favoring more tendency for curable radical resection even in large swellings or capsular invasion, as conclusion it is important to differentiate this tumor from other pancreatic neoplasms because this neoplasm is amenable to cure after complete surgical resection, unlike malignant tumors of the pancreas. We aim to review the current literatures regarding the diagnosis, management, and outcomes of patients with solid pseudopapillary neoplasms of the pancreas.

Solid pseudopapillary neoplasm of the pancreas: Report of a rare case and review of the literature on an enigmatic entity