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Neurofibromas comprise a unique subset of peripheral nerve sheath tumors defined by their distinct anatomic location and distinguished by their histologic diversity. Neurofibromas can be a part of Neurofibromatosis 1 (NF1). Most Neurofibromas are histologically benign however, they may experience malignant degeneration especially in the setting of neurofibromatosis. A total of 27 cases of neurofibroma and 5 cases of malignant peripheral nerve sheath tumor and their variants are included in this study. Neurofibromas spans a wide range of histopathological features and associated clinical characteristics. Our study focuses on histopathology of Neurofibroma and Malignant peripheral nerve sheath tumor and emphasizes the histologic attributes to be familiar with these entities and establish their accurate pathological diagnosis in view of their varying biologic behavior.

A histopathological study of neurofibroma and malignant peripheral nerve sheath tumors in a medical institute of Central Karnataka