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Background: Gall bladder is very common organ to be affected by many pathological diseases which include wide spectrum of the lesions from congenital ones to inflammatory or premalignant and malignant lesions. Aim: Study the spectrum of histopathological lesions in gallbladder in Cholecystectomy specimens. Material and Methods: The study was conducted in the Department of Pathology, Muzaffarnagar Medical College, Muzaffarnagar. Total of 434 cholecystectomy specimen were studied. Result: Maximum cases (231/434 cases) were of chronic cholecystitis followed by acute cholecystitis (28 cases), eosinophilic cholecystitis (3 cases), cholesterolosis (31 cases), follicular cholecystitis (11 cases), xanthogranulomatous cholecystitis (9 cases) and one case each of mucocele and porcelain gall bladder. Metaplasia was seen in 83 cases (19.12%), dysplasia in 16 cases (3.68%) and malignancy in 5 cases (1.15%). Conclusion: Gall bladder with stones of prolonged duration associated with risk of premalignant and malignant conditions making histopathological examination necessary for timely recognization of

The spectrum of histopathological lesions in Gallbladder in cholecystectomy specimens