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Background: Wild animal handlers are at continuous risk of exposure to rabies. They have to be protected against rabies by pre-exposure rabies vaccination and regular booster doses. Methodology: The study was conducted in a biological park in Karnataka during October 2018. Animal handlers working in the various capacities at the park and having taken three primary doses of anti-rabies vaccine as pre-exposure prophylaxis were the study subjects. The booster dose of antirabies vaccine was administered by a team of trained vaccinators. After the vaccination all the subjects were observed for any adverse reactions for thirty minutes; subsequently the subjects were followed up for any adverse drug reactions through telephone for a period of 30 days. Results: The study included 198 subjects with a mean age of 38.1 + 12 years. Only 8 adverse reactions were reported from 8 subjects immediately following vaccination. The adverse reactions were itching 3 (1.5%) & redness 5 (2.5%); which subsided without any complications. None of the subjects developed systemic or delayed adverse reactions. Conclusion: Booster dose rabies vaccination with purified chick embryo cell rabies vaccine is safe in previously vaccinated animal handlers.

Safety of purified chick embryo cell rabies vaccine administered in previously vaccinated animal handlers working in a biological park