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Background: Deep sedation required for magnetic resonance imaging (MRI) in paediatric age group is a challenge. This study is done to compare the sedative and hemodynamic effects of dexmedetomidine with ketamine (DK) in comparison to propofol with midazolam (PM) in children undergoing MRI. The primary objective is to compare the recovery time and recovery characteristics between the drug combination and secondary objectives were to compare the efficacy and adverse events between the two groups.Methods: This is a double blind randomised controlled study involving 100 patients posted for MRI in a tertiary care hospital between 01 Jan 2017 to 31 Dec 2018. Statistical analysis tests performed to compare the results between the two groups.Results: The average time to achieving the Aldrete score of 10/10 in DK group was 25.43 min as compared to 13.7 min in PM group which is statistically significant. Also, time to achieve Ramsay Sedation Scale (RSS) scale of 5 was significantly higher in the DK group (12.20min) in comparison to PM group (6.30 min). There was no significant difference between heart rate, respiratory rate, systolic blood pressures or oxygen saturation during the procedure.Conclusion: Combination of propofol with midazolam provided statistically significant rapid rates of anaesthetic induction as well as recovery when compared with dexmedetomidine ketamine group.

Comparison of dexmedetomidine-ketamine and propofol-midazolam in children undergoing MRI: A prospective randomised study