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Background: Neonatal jaundice is accountable for 70% neonatal morbidity and 10% mortality. It is the most common cause of re-admission after discharge from hospital. Here, we have studied the effect of Fenofibrate as an adjunct to phototherapy in treating neonatal hyperbilirubinemia. Materials and Methods: This study was conducted on 90 neonates with hyperbilirubinaemia requiring phototherapy, they were randomly allocated to two groups, both the groups received phototherapy whereas the intervention group received single dose of fenofibrate (10mg/kg) in addition. Total serum bilirubin after 48 hours and duration of phototherapy was measured in both groups. Results: The study proved that there is a decrease in duration of phototherapy and decline in serum bilirubin after 48 hours of phototherapy in intervention group, but the difference is not statistically significant. Conclusion: There is a non-significant role of Fenofibrate in decreasing neonatal hyperbilirubinemia.

The efficacy of fenofibrate as an adjunct to phototherapy for neonatal hyperbilirubinemia