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Background: Extracapsular cataract extraction (ECCE) with implantation of posterior chamber intraocular lens (PC IOL) is currently the surgery of choice for cataract, with the success rate of over 95%. Objectives: To earmark clinical superiority of either of the drugs given prophylactically in managing intraocular pressure spikes following Nd:YAG laser posterior capsulotomy. Method: The present study was conducted on 100 patients, who had developed posterior capsule opacification following successful cataract surgery with intraocular lens implantation and underwent Nd:YAG laser posterior capsulotomy in the Outpatient Department of Ophthalmology, RMCH. Results: In Apraclonidine group, pressure differences with control group were evident at 3 hours (ΔP3) & at 24 hours (ΔP24) that were highly statistically significant; (p=0.0078 & 0.0045 for ΔP3 & ΔP24 respectively). The same were not significantly different (p> 0.05) at 1 hour or day 7 following laser application. The Briminodine group demonstrated significant differences in pressure fluctuations compared with control group at all recorded times with maximum variation noted at 3 hours post capsulotomy (p=0.000015). Conclusion: It was concluded Both Apraclonidine & Briminodine are found useful drug interventions in laser therapy, but Briminodine clearly scores over former in dampening the IOP rise.

international journal of medical ophthalmology

Clinical superiority of either of topical 0.5% apraclonidine, 0.2% brimonidine and 0.03% bimatoprost given prophylactically in managing intraocular pressure spikes following Nd:YAG laser posterior capsulotomy