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Cyprinid herpesvirus 3 is an important pathogen and the causative agent of koi herpesvirus disease, which has been associated with mass mortalities in koi and common carp Cyprinus carpio. Currently, the only available commercial vaccine is an attenuated version of the virus. This has led to concerns about its risk to reversion to virulence. Furthermore, the vaccine is currently only available in Israel and the United States. In order to investigate the antigenic profile of the virus, western blot was performed using infected cell culture supernatant and sera from carp that had survived exposure to the virus. Only one antigen could be detected, and mass spectrometry analysis identified the corresponding protein as ORF 12, a putative secreted tumour necrosis factor receptor homologue. In other herpesviruses, such proteins have been associated with the viral infectious process in a number of ways, including the entry into the host cell and the inhibition of apoptosis in infected cells. The reason why only one antigen could be detected during this study is unknown.

Non-structural protein pORF 12 of cyprinid herpesvirus 3 is recognized by the immune system of the common carp Cyprinus carpio