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An e p ~ s o d e of acute mortality that occurred in a population of pond-reared fingerling stnped bass Morone saxat~lis in northern Cal~fornia, USA, was ~nvestigated Affected fish were darkened and had bilateral exophthalmos and abdominal d~stension Livers were enlarged and pale, and a small amount of a serous f l u~d was present in the pleuroperltoneal cav~ ty Microscop~c examination revealed panhepatic megalocytosis w ~ t h i n d ~ v ~ d u a l hepatocyte degeneration and necrosis Electron microscopic examinat~on of hepatocytes revealed lnvaginat~ons of the nuclear membrane and subsequent hern~ation of the perinuclear cytoplasm into the nucleus Mortality among fish moved from the pond to the laboratory decllned and then ceased after 8 wk, prov~dlng an opportunity for s e r ~ a l analysis of repalr and resolut~on At 12 d post-subm~ssion proliferation of bile ductular epithel~al cells occurred adjacent to foci of degenera t~ve hepatocytes prlor to regeneration of morphologically normal hepatocytes Multifocal areas of exocrine pancreat~c metaplasia were also present at 12 d and persisted until the termlnat~on of the study The etiology of the disease was not de t e rmned but standard procedures ruled out a primary microbial Infection Hepatotoxic agents under cons~de ra t~on Include pyrroliz~dine alkaloids and blue-green algal phytotoxlns These observations ~ n d ~ c a t e that the striped bass 1s sens l t~ve to potentlal toxicants but is capable of repair and regeneratlon following sublethal injury A pluripotent stem cell capable of differentiation into 3 epithelia1 cell types may be essential for t h ~ s repalr and regeneration Experimental exposure s t u d ~ e s are In progress to identify the e t~o log~ca l gent and further study the pathogenesis of the hepatic lesions

diseases of aquatic organisms

Progression and resolution of megalocytic hepatopathy with exocrine pancreatic metaplasia in a population of cultured juvenile striped bass Morone saxatilis