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Interdisciplinary Graduate Program for the Biological and Biomedical Sciences, Vanderbilt University, Nashville, Tennessee 37212, USA Department of Biology, College of William and Mary, 3035 Integrated Science Center, Williamsburg, Virginia 23185, USA Laboratory of Retroviruses, Division of Viral Products, Center for Biologics Evaluation & Research, U.S. Food & Drug Administration, Bethesda, Maryland 20892, USA

Optimization of viral profiling approaches reveals strong links between viral and bacterial communities in a eutrophic freshwater lake