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Using immunohistochemistry, we studied the expression of S100A4 and E-cadherin in 43 oral squamous cell carcinomas (SCC) to evaluate the metastatic potential and patient survival. Expression levels of S100A4 correlated with lymph node metastasis (P=0.024) and poor prognosis (P=0.0136). Reduced E-cadherin expression was also associated with lymph node metastasis (P=0.023) and poor prognosis (P=0.0146) and was inversely correlated with S100A4 expression (P=0.011). We also found that S100A4(2+,3+)/E-cadherin(-,+) expression was significantly associated with lymph node metastasis (P=0.04) and poor prognosis (P=0.0021). Furthermore, we systematized the evaluation of oral SCC metastasis and prognosis by analyzing the expression of S100A4, E-cadherin, and other histopathological factors. Cases with total points greater than 8 were associated with lymph node metastasis (P=0.000) and poor prognosis (P=0.0022). These results indicate that S100A4, as both a single factor and in combination with E-cadherin, may be one of the most useful markers predicting the metastatic potential and prognosis of oral SCC patients.

The Evaluation of both Metastasis and Prognosis of Oral Squamous Cell Carcinoma by S100A4 and E-cadherin Immunostaining