English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The recent development of innovative therapeutic techniques has improved the survival rate of allogeneic stem cell transplantation (Allo-SCT) recipients with hematologic malignancies; however, noninfectious pulmonary complications as a result of chronic graft-versus-host disease (GVHD) still remain a frequent cause of transplant-related death (1, 2). Among the late-onset noninfectious pulmonary complications associated with chronic GVHD, thoracic air-leakage syndrome (ALS), which worsens the survival rate, has been addressed in several reports of patients with bronchiolitis obliterans (BO) (3). Although ALS manifesting as pneumomediastinum, subcutaneous emphysema, pneumothorax, and pneumopericardium is a rare complication, its clinical course and cause of poor prognosis have not been well understood. To the best of our knowledge, there have only been a few reports regarding ALS in Allo-SCT recipients. Herein, we present two cases of ALS with BO in chronic GVHD patients after Allo-SCT and report their clinical course, computed tomography (CT) findings, and finally death.

Thoracic Air-Leakage Syndrome in Allogeneic Stem Cell Transplant Recipients as a Late Complication of Chronic Graft-versus-Host Disease: Case Reports