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The combination Phyllanthus niruri L. and Chloramphenicol which is known to have additive interactions on the inhibition of S.aureus. The use of Standardized Herbal Medicine traditional medicines is used because the ingredients have standardized and that have been tested in preclinical terms, but there has been no research on SHM combination P.niruri and Chloramphenicol on growth S.aureus.The use of herbal medicines as a companion to synthetic drugs in the community is the basis for testing to determine inhibition and SHM interactions P.niruri with Chloramphenicol against S.aureus. Method: To determine the inhibitory potential, a zone of inhibition was measured using the method Kirby-Bauer between the SHM combination of P.niruri and Chloramphenicol, the use of SHM doses P.niruri based on recommended dose (183.3ppm) and half the recommended drinking dose (91.65 ppm). Phytochemical testing was carried out to determine the content of active compounds contained in SHM P.niruri. Clear zone measurements were taken to determine the inhibitory effect of antibiotics measured using a caliper. Antibiotic interactions were interpreted using the Ameri-Ziaei Double Antibiotic Synergism Test (AZDAST) method and based on statistical data (p <0.05). Result: : Phytochemical test SHM P.niruri obtained the content of active compounds in the form of flavonoids and saponins. Combination of SHM P.niruri and Chloramphenicol at a dose of 183.3ppm produce clear zone 15.17±0.09 mm greatter than at a dose of 91.65 ppm which produces a clear zone of 14.09 ± 2.18 mm. Conclusion: Determination of interaction ZOI combination SHM P.niruri and Chloramphenicol has an interaction that cannot be distinguished (Not Distinguishable).

Efek Pemberian Kombinasi Obat Herbal Terstandar Phyllanthus Niruri L. Dengan Chloramphenicol Terhadap Daya Hambat Pertumbuhan Staphylococcus Aureus