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The aim of the study was to explore the possible molecular markers of chloroquine resistance in Plasmodium vivax isolates in Thailand. A total of 30 P. vivax isolates were collected from a malaria endemic area along the Thai-Myanmar border in Mae Sot district of Thailand. Dried blood spot samples were collected for analysis of Pvmdr1 and Pvcrt-o polymorphisms. Blood samples (100 μl) were collected by finger-prick for in vitro chloroquine susceptibility testing by schizont maturation inhibition assay. Based on the cut-off IC50 of 100 nM, 19 (63.3%) isolates were classified as chloroquine resistant P. vivax isolates. Seven non-synonymous mutations and 2 synonymous were identified in Pvmdr1 gene. Y976F and F1076L mutations were detected in 7 (23.3%) and 16 isolates (53.3%), respectively. Analysis of Pvcrt-o gene revealed that all isolates were wild-type. Our results suggest that chloroquine resistance gene is now spreading in this area. Monitoring of chloroquine resistant molecular markers provide a useful tool for future control of P. vivax malaria.

korean journal of parasitology

&amp;lt;I&amp;gt;Plasmodium vivax&amp;lt;/I&amp;gt; Drug Resistance Genes; &amp;lt;I&amp;gt;Pvmdr1&amp;lt;/I&amp;gt; and &amp;lt;I&amp;gt;Pvcrt-o&amp;lt;/I&amp;gt; Polymorphisms in Relation to Chloroquine Sensitivity from a Malaria Endemic Area of Thailand