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The purpose of this study was to examine whether there are the associations between TNF alpha and TNF beta gene polymorphisms and the development and progression of Ig A nephropathy (IgAN). A cross-sectional study on TNF alpha and TNF betagene polymorphisms by polymerase chain reaction with restriction fragment length poly-morphisms was performed on 76 patients with primary IgAN confirmed by renal biopsy and 100 healthy controls. The allele with G--&gt;A substitution was designated as TNFA2 for the TNF alpha gene and TNFB2 for the TNF betagene. A patient in whom dialysis treatment was started or whose serum creatinine became double or over during the follow-up duration was designated as a "progressor". The TNFA2/ TNFA2 genotype was more prevalent in the progressor than in the non-pregressor group (20.0 vs 3.3%, p&lt;0.05). Clinical factors such as serum creatinine, systolic and diastolic blood pressure (p&lt;0.001, respectively) were higher and pathologic factor such as Grade IV or V renal lesions was more prevalent (p&lt;0.01) in the progressor than in the non-progressor group. Therefore, TNFA2/TNFA2 genotype may be a risk factor for the progression of IgAN.

Is Tumor Necrosis Factor Genotype (TNFA2/TNFA2)a Genetic Prognostic Factor of an Unfavorable Outcome in IgA Nephropathy?