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Allergic dermatosis occupies one of the leading places in structure of the general disease of a skin and hypodermic cellular tissue and makes 56,2 % among skin diseases [1,2,5,13]. On the basis of formation of allergic dermatosis lays interaction of various genetic factors with environmental factors [3,4,6-10,12]. One of the effective approaches to studying of mechanisms of allergic dermatosis development is connected with research of the genes, products which can be expressly or by implication involved in development of the given pathology [11,17-22].

The Role of Genes Enzymes Xenobiotics in The Mechanisms of Formation of Heavy Severity Level of Allergic Diseases in Uzbekistan