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Background: Thyroid dysfunction has been associated with kidney function decline. Biochemical markers of thyroid dysfunction that correlate with stages of chronic kidney disease (CKD) in sub-Saharan Africa are not well known. We therefore decided to determine the correlation between biomarkers of thyroid dysfunction and CKD in Cameroon. Methods: A cross-sectional study was conducted in two health facilities involving patients (≥ 18 years old) diagnosed with CKD. A questionnaire was used to collect socio-demographic and clinical data from the participants and their medical records. Thyroid hormone profile and Serum creatinine levels were analyzed. Urine albumin creatinine ratio (ACR) was estimated. CKD was defined as eGFR<60 ml/min/1.73 m2 or urinary ACR ≥ 30mg/g. Results: Out of the 366 patients, 233 (63.66%) were male and the mean age was 55.85 (± 13.72) years. The mean TT3, FT3 and FT4 were found to decrease as the CKD stages increase. The prevalence of thyroid dysfunction was 57%. There was a significant correlation between thyroid hormone profile (TT4, TT3, FT4, FT3) and stages of CKD (Spearman’s rho = -0.173, -0.229, -0.166, -0.45 respectively; p <0.05). These observations were supported by the positive correlation observed between thyroid hormone profile (FT4, FT3, TT3) and the estimated glomerular filtration rate (Pearson’s correlation: r = 0.425, 0.188, 0.285, 0.003 respectively; p <0.05). No correlation was found between TSH level and stages of CKD. Conclusion: There exist significant correlations between biomarkers of thyroid dysfunction and stages of Chronic Kidney Diseases in the Cameroonian population.

Correlation Between Biomarkers of Thyroid Function Abnormalities and Stages of Chronic Kidney Disease in Cameroon