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Pre-eclampsia (P-EC) is a major cause of maternal and neonatal mortality and morbidity. Despite intensiveresearch, its aetiology remains poorly understood. However, underlying maternal cardiovascular risk factors arethought to be implicated. Changes in the maternal vasculature and coagulation profile may predispose womenwith P-EC to subsequent adverse cardiovascular consequences. Here we investigate the relationship betweencirculating levels of haemostatic factors and inflammatory cytokines in women with a previous history of P-EC.The participents included 26 women who had had P-EC within the last three years and were more than 6 monthspostpartum and 14 age-matched healthy women with no past history of P-EC. Blood was collected and assayed forplasma IL-6, IL-8, TNF-α and IL-10, Tissue Factor (TF) and TF-Pathway Inhibitor (TFPI), using Enzyme-LinkedImmunosorbent Assays.Individually, plasma TF, IL-6, IL-8 and IL-10 levels increased in the P-EC group compared with their normalcounterparts, whereas plasma TFPI and TNF-α level were reduced. Plasma TF/TFPI ratios and IL-10 valueswere significantly increased in the P-EC group compared with controls (p<0.05, p<0.01, respectively). There werepositive and significant correlations between TFPI and IL-10 (r= 0.5; p<0.01) and TF/TFPI ratio and IL-10 (r=0.31; p<0.041), and between IL-6 and TNF-α (r=0.71; p<0.001) and IL-6 and IL-10 (r=0.42; p<0.01).In conclusion, our results suggest the presence of elevated inflammatory cytokines and an imbalance of thehaemostatic system in women with a past-history of P-EC, which may contribute to the known increased risk ofcardiovascular disease in these women later in life.

Inflammatory and Haemostatic Changes Following Pre-eclampsia: Potential Link with Development of Subsequent Cardiovascular Events?