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Streptococcus pneumoniae is one of the most common pathogens of otitis media (OM) that exists in biofilm, which enhances the resistance of bacteria against antibiotic killing and diagnosis, compared to the free-floating (planktonic) form. This study evaluated biofilm formation by S. pneumoniae on an abiotic surface and in the middle ear cavity in a rat model of OM.

clinical and experimental otorhinolaryngology

In VitroStreptococcus pneumoniaeBiofilm Formation andIn VivoMiddle Ear Mucosal Biofilm in a Rat Model of Acute Otitis Induced byS. pneumoniae