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This paper briefly presents the progress and results developed within the framework of the PhD thesis entitled "Methodology for Layout Optimization and Process Synthesis Considering Technological Risk". Through it, it is intended to develop an efficient algorithm that allow to obtain the optimal distribution of the process units and the departments present in the industrial plant under the consideration of the inherently safe design philosophy, including the main structural design restrictions. For the implementation of such an algorithm, optimization models have been developed that allow to connect decision-making in the conceptual design stage and in the layout design stage through the contemplation of the edges common to both stages, considering both the vulnerability of the interior of the plant and the surroundings (homes, schools, hospitals, etc.). This link was carried out through the development of reduced models for the evaluation of the impact of different accidental events

Optimización Simultánea del Diseño Conceptual de Procesos y Layout de Planta Considerando el Riesgo Tecnológico