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Dear Editor,  Syphilis is a sexually transmitted, systemic infection with increasing prevalence. Ocular syphilis may develop at any stage of the disease process and can involve any ocular structure [1]. Ocular syphilis mimics any type of inflammatory process without pathognomonic manifestations and often leads to misdiagnosis, resulting in permanent vision loss [1,2]. Syphilitic uveitis involving the posterior segment has been reported as several conditions [1]; however, to our knowledge, no previous study describing syphilitic outer retinitis has examined the condition by spectral-domain optical coherence tomography (SD-OCT). Herein, we report a case of syphilitic outer retinopathy, mimicking acute zonal occult outer retinopathy (AZOOR).  A 59-year-old man presented with a 2-week history of blurred vision in the right eye. Visual acuity was 20 / 30 in right eye and 20 / 20 in left eye. Slit-lamp examination and fundoscopy were normal (Fig. 1A). Fundus fluorescein angiography showed no abnormality in early and late phases (Fig. 1B). However, fundus autof luorescence imaging showed hyperfluorescence around the macula, while SD-OCT revealed a diffuse disruption of the photoreceptor inner segment-outer segment (IS-OS) junction line in the macula in the right eye (Fig. 1C and 1D). Multifocal electroretinography (ERG) revealed reduced amplitudes in the centermost and inferior retinal areas which corresponded to the area of visual field defect on Humphrey visual field (HVF) perimetry, and to the area of disrupted photoreceptors at the IS-OS junction line on SD-OCT (Fig. 1E and 1F). Full-field ERGs were normal and symmetric. The patient's medical history and laboratory tests were unremarkable; serologic tests for syphilis were not performed.    Fig. 1  Summary of clinical and diagnostic features. At initial visit, color fundus photography (A) and fundus f luorescein angiography (A) showed normal appearance. However, fundus autofluorescence (FAF) imaging (C) and spectral-domain optical coherence tomography ...    We initially diagnosed him with AZOOR, based on acute loss of visual acuity, fundoscopy, and ERG findings [3]. The patient received 15 mg/day oral prednisolone for 1 month, which was then tapered to 10 mg/day for 2 months. Since vision improved to 20 / 25 and photoreceptor disruption was partially restored after treatment (Fig. 1G), we added oral methotrexate (15 mg/wk). However, at 5 months, vision decreased to 20 / 30, vitreous opacity developed, and photoreceptor disruption progressed on SD-OCT (Fig. 1H). At 6 months, the photoreceptor disruption worsened and his vision deteriorated to 20 / 50 (Fig. 1I). Complete serologic tests were performed, which diagnosed him as active syphilis (both the Venereal Disease Research Laboratory assay and fluorescent treponemal antibody-absorption test were positive). We diagnosed him with syphilitic outer retinopathy in right eye and discontinued immunosuppressant therapy and intramuscularly administered 2.4 million units of benzathine penicillin G three times per week. One month later, vision had improved to 20 / 30, and the disruption of photoreceptor on SD-OCT was partially restored (Fig. 1J). At 3 months after antibiotics therapy, vision had improved to 20 / 20 and SD-OCT showed complete restoration of photoreceptor function (Fig. 1K). Multifocal ERG and HVF revealed complete normalization (Fig. 1L and 1M).  AZOOR is a rare disease of unknown etiology and is characterized by focal degeneration. While associated with both ocular and systemic diseases [3,4], syphilis has never been reported as mimicking AZOOR in Korea. Given the clinical presentation and the lack of syphilis as differential diagnosis, we diagnosed AZOOR without exploring other possible causes. Based on this case, we suggest that syphilitic retinitis should be considered as a differential diagnosis for AZOOR, and that meticulous serologic tests should be performed prior to a diagnosis of AZOOR. In this case, SD-OCT was helpful in the evaluation and monitoring of photoreceptor damage, and the results were correlated with visual function.  Although syphilitic retinitis has increased with an increasing global incidence of syphilis [5], its pathogenesis remains controversy [2,4]. However, given the response to antibiotics therapy, our case substantiates that syphilitic retinitis occurred via direct invasion of spirochetes into the lesion, rather than by an autoimmune reaction as a result of molecular mimicry. Photoreceptor disruption completely recovered with antibiotic therapy; timely administration of systemic antibiotics is thus warranted for rescuing vision in eyes with syphilitic retinitis. Furthermore, SD-OCT accurately reflected the status of photoreceptor disruption at diagnosis, as well as efficacy of therapeutic intervention.  Acute syphilitic posterior placoid chorioretinitis should be also suspected as a differential diagnosis. In our case, however, we ruled out acute syphilitic posterior placoid chorioretinitis based on normal fluorescein angiography results.  In conclusion, clinical suspicion of syphilitic outer retinitis in patients presenting as AZOOR is crucial for early diagnosis and treatment. Photoreceptor evaluation using SD-OCT can be useful for diagnosis and monitoring response to treatment.

A Case of Syphilitic Outer Retinitis Mimicking Acute Zonal Occult Outer Retinopathy