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Purpose: We compared anterior segment measurements obtained using a Scheimpflug-Placido topographer (SIRIUS®, Costruzione Strumenti Oftalmici, Florence, Italy) and a new anterior module for a swept-source optical coherence tomography system (ANTERION®, Heidelberg Engineering Inc., Heidelberg, Germany).Methods: Anterior segment measurements were evaluated in 74 eyes of 101 patients with the two devices. Central corneal thickness (CCT), anterior chamber depth (ACD), corneal refractive power (K), J0 (Jackson cross-cylinder with axes at 180° and 90°), J45 vector (Jackson cross-cylinder with axes at 45° and 135°), and white-to-white corneal diameter (WTW) measurements obtained using the SIRIUS® system and the new anterior segment module of ANTERION® were compared.Results: The mean CCTs measured by SIRIUS® and ANTERION® were 558.69 ± 44.65 and 540.26 ± 36.57 μm, respectively. The difference was statistically significant (p &lt; 0.005), and there were high correlations between the two methods (r = 0.915, p &lt; 0.001). The mean ACD measurements were 3.34 ± 0.53 and 3.34 ± 0.51 mm (p = 0.856), respectively, for SIRIUS® and ANTERION®. The measurements were strongly correlated (r = 0.966, p &lt; 0.001). The measurements of WTW, total mean K, and J0 obtained with the two systems differed significantly (p &lt; 0.005, p = 0.017, and p &lt; 0.005, respectively), with high correlations between the two systems (r = 0.875, r = 0.967, and r = 0.933, respectively; all p &lt; 0.001).Conclusions: There were significant differences in measurements of K, CCT, WTW, and J0 between the two devices. Agreement analysis suggests that SIRIUS® and ANTERION® should not be used interchangeably.

Comparison of Anterior Segment Measurements between Scheimpflug-Placido Camera and New Swept-source Optical Coherence Tomography