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. HIV infection is one of the most relevant diseases from a medical, epidemiological and social point of view. Timely diagnosis, detection and control of the disease, adequate prescription of antiretroviral therapy can sufficiently reduce the viral load on the patient's body, reduce the risk of transmission of infection. Currently, combinations of various antiretroviral drugs are increasingly being prescribed as therapy. One of the most important is combination of atazanavir and ritonavir. The most important stage for the study of pharmacokinetics, studies of comparative pharmacokinetics and bioequivalence is the development of an analytical method that allows you to determine the investigated substances in human plasma. There are currently no published methods for the determination of atazanavir and ritonavir in human plasma using high performance liquid Доклинические и клинические исследования Preclinical and clinical study © Комаров Т. Н., Шохин И. Е., Мискив О. А., Богданова Д. С., Алешина А. В., Медведев Ю. В., Багаева Н. С., 2020 © Komarov T. N., Shohin I. E., Miskiv O. A., Bogdanova D. S., Aleshina A. V., Medvedev Yu. V., Bagaeva N. S., 2020

Development and Validation of Atazanavir and Ritonavir Determination in Human Plasma by HPLC-MS Method