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. Even though a wide range of the products for caries treatment is available, the efficiency of its treatment with the traditional methods is 62,5–75,4%. As a result of the set of researches carried out at the Department of Pharmaceutical Technology of the Perm State Pharmaceutical Academy, in cooperation with the Department of Dentistry of the Advanced Training and Professional Retraining Faculty of E. A. Wagner Perm State Medical University, a medical method of moderate and advanced caries treatment with remineralizing gel and films is proposed. During the preparation of the product specification file for the dentin caries treatment film, validation of the methods of the active ingredients quality control has been undertaken. Aim. Validation of the methods of identity tests and of potency assays of dentin caries treatment films. Materials and methods. In order to achieve the aim, active pharmaceutical substances of pharmacopoeial quality have been used. As a base for developing the methods of identity tests the methods with distinctive reactions to cations and anions have been taken. For the potency assay of calcium chloride a complexometric back-titration has been used; photoelectric colorimetry for potassium phosphate dibasic and sodium fluoride; spectrophotometry for chlorhexidine bigluconate. Five production samples of the films were the object of the research. Методы анализа лекарственных средств Analytical Methods © Березина Е. С., Голованенко А. Л., Алексеева И.В., 2019 © Berezina E. S., Golovanenko A. L., Alekseeva I. V., 2019

Validation of Methods of Identification and Quantitative Determination of Active Ingredients in Films for Treatment of Caries of Dentin